Myocarditis, pericarditis, and COVID-19 mRNA-vaccination

Pathum Sookaromadee, Viroj Wiwanitkit


[no abstract, showing first paragraph]

Dear Editor, 

We would like to share ideas on “Myocarditis and pericarditis in association with COVID-19 mRNA-vaccination: cases from a regional pharmacovigilance centre” [1]. Istampoulouoglou et al. concluded that “In 16 of the 17 cases (94%), the association between the AEFI and mRNA-vaccination was considered possible …..[1].” 

We agree that COVID-19 vaccination might cause adverse effects, and myocarditis is an important one.  However, it is difficult to clearly state that the vaccine cause the problem. The pathogenesis of vaccine-related myocarditis is still unclear. It might be an immunopathology. In that case, an abnormal immune parameter will be an important clue. However, it usually lacks for data and it cannot rule out pre-vaccination occult abnormal immunity. 

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