Macrophage migration inhibitory factor (MIF) in the development and progression of pulmonary arterial hypertension

Mohamed Ahmed, Edmund Miller

Abstract


Macrophage migration inhibitory factor (MIF) has been described as a pro-inflammatory cytokine and regulator of neuro-endocrine function. It plays an important upstream role in the inflammatory cascade by promoting the release of other inflammatory cytokines such as TNF-alpha and IL-6, ultimately triggering a chronic inflammatory immune response. As lungs can synthesize and release MIF, many studies have investigated the potential role of MIF as a biomarker in assessment of patients with pulmonary arterial hypertension (PAH) and using anti-MIFs as a new therapeutic modality for PAH.


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DOI: http://dx.doi.org/10.21542/gcsp.2018.14

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Copyright (c) 2018 Mohamed Ahmed, Edmund Miller

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