Macrophage migration inhibitory factor (MIF) in the development and progression of pulmonary arterial hypertension
Abstract
Macrophage migration inhibitory factor (MIF) has been described as a pro-inflammatory cytokine and regulator of neuro-endocrine function. It plays an important upstream role in the inflammatory cascade by promoting the release of other inflammatory cytokines such as TNF-alpha and IL-6, ultimately triggering a chronic inflammatory immune response. As lungs can synthesize and release MIF, many studies have investigated the potential role of MIF as a biomarker in assessment of patients with pulmonary arterial hypertension (PAH) and using anti-MIFs as a new therapeutic modality for PAH.
Full Text:
PDFDOI: http://dx.doi.org/10.21542/gcsp.2018.14
Refbacks
- There are currently no refbacks.
Copyright (c) 2018 Mohamed Ahmed, Edmund Miller

This work is licensed under a Creative Commons Attribution 4.0 International License.