Prospective study of tricuspid valve regurgitation associated with permanent leads in patients undergoing cardiac rhythm device implantation: Background, rationale, and design

Authors

  • Hisham Dokainish McMaster University, Hamilton, ON, Canada
  • Esam Elbarasi McMaster University, Hamilton, ON, Canada
  • Simona Masiero Universita’ Politacnica delle Marche, Ancona, Italy
  • Caroline Van de Heyning Antwerp University Hospital, Antwerp, Belgium
  • Michela Brambatti Universita’ Politacnica delle Marche, Ancona, Italy
  • Sami Ghazal McMaster University, Hamilton, ON, Canada
  • Said AL-Maashani McMaster University, Hamilton, ON, Canada
  • Alessandro Capucci Universita’ Politacnica delle Marche, Ancona, Italy
  • Lisanne Buikema McMaster University, Hamilton, ON, Canada
  • Darryl Leong McMaster University, Hamilton, ON, Canada
  • Bharati Shivalkar Antwerp University Hospital, Antwerp, Belgium
  • Johan Saenen Antwerp University Hospital, Antwerp, Belgium
  • Hielko Miljoen Antwerp University Hospital, Antwerp, Belgium
  • Carlos Morillo McMaster University, Hamilton, ON, Canada
  • Syam Divarakarmenon McMaster University, Hamilton, ON, Canada
  • Guy Amit McMaster University, Hamilton, ON, Canada
  • Sebastien Ribas McMaster University, Hamilton, ON, Canada
  • Aaron Brautigam McMaster University, Hamilton, ON, Canada
  • Erika Baiocco Universita’ Politacnica delle Marche, Ancona, Italy
  • Alessandro Maolo Universita’ Politacnica delle Marche, Ancona, Italy
  • Andrea Romandini Universita’ Politacnica delle Marche, Ancona, Italy
  • Simone Maffei Universita’ Politacnica delle Marche, Ancona, Italy
  • Stuart Connolly McMaster University, Hamilton, ON, Canada
  • Jeff Healey McMaster University, Hamilton, ON, Canada

Abstract

Given the increasing numbers of cardiac device implantations worldwide, it is important to determine whether permanent endocardial leads across the tricuspid valve can promote tricuspid regurgitation (TR). Virtually all current data is retrospective, and indicates a signal of TR being increased after permanent lead implantation. However, the precise incidence of moderate or greater TR post-procedure, the exact mechanisms (mechanical, traumatic, functional), and the hemodynamic burden and clinical effects of this putative increase in TR, remain uncertain. We have therefore designed a multicenter, international, prospective study of 300 consecutive patients (recruitment completed, baseline data presented) who will undergo echocardiography and clinical assessment prior to, and at 1-year post device insertion. This prospective study will help determine whether cardiac device-associated TR is real, what are its potential mechanisms, and whether it has an important clinical impact on cardiac device patients.

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Published

2017-09-07

Issue

Vol. 2015 No. 3 (2015)

Section

Research articles

License

This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.