NaNog: A pluripotency homeobox (master) molecule

Authors

  • Mona H Allouba Aswan Heart Centre, Aswan, Egypt
  • Ahmed M ElGuindy Aswan Heart Centre, Aswan, Egypt
  • Navaneethakrishnan Krishnamoorthy 2. Qatar Cardiovascular Research Centre, Doha, Qatar 3. Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, UK
  • Magdi H Yacoub 1. Aswan Heart Centre, Aswan, Egypt 2. Qatar Cardiovascular Research Centre, Doha, Qatar 3. Harefield Heart Science Centre, National Heart and Lung Institute, Imperial College London, UK
  • Yasmine E Aguib Aswan Heart Centre, Aswan, Egypt

Abstract

[first paragraph of article]

One of the most intriguing aspects of cell biology is the state of pluripotency, where the cell is capable of self-renewal for as many times as deemed “necessary”, then at a specified time can differentiate into any type of cell. This fundamental process is required during organogenesis in foetal life and importantly during tissue repair in health and disease. Pluripotency is very tightly regulated, as any dysregulation can result in congenital defects, inability to repair damage, or cancer. Fuelled by the relatively recent interest in stem cell biology and tissue regeneration, the molecules implicated in regulating pluripotency have been the subject of extensive research. One of the important molecules involved in pluripotency, is NaNog, the subject of this article.

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Published

2017-09-07

Issue

Section

Molecule of the month