Computational fluid dynamics applied to virtually deployed drug-eluting coronary bioresorbable scaffolds: Clinical translations derived from a proof-of-concept

Bill D Gogas, Boyi Yang, Tiziano Passerini, Alessandro Veneziani, Marina Piccinelli, Gaetano Esposito, Emad Rasoul-Arzrumly, Mosaab Awad, Girum Mekonnen, Olivia Y Hung, Beth Holloway, Michael McDaniel, Don Giddens, Spencer B King III, Habib Samady

Abstract


Background: Three-dimensional design simulations of coronary metallic stents utilizing mathematical and computational algorithms have emerged as important tools for understanding biomechanical stent properties, predicting the interaction of the implanted platform with the adjacent tissue, and informing stent design enhancements. Herein, we demonstrate the hemodynamic implications following virtual implantation of bioresorbable scaffolds using finite element methods and advanced computational fluid dynamics (CFD) simulations to visualize the device-flow interaction immediately after implantation and following scaffold resorption over time. 

Methods and Results: CFD simulations with time averaged wall shear stress (WSS) quantification following virtual bioresorbable scaffold deployment in idealized straight and curved geometries were performed. WSS was calculated at the inflow, endoluminal surface (top surface of the strut), and outflow of each strut surface post-procedure (stage I) and at a time point when 33% of scaffold resorption has occurred (stage II). The average WSS at stage I over the inflow and outflow surfaces was 3.2 and 3.1 dynes/cm2respectively and 87.5 dynes/cm2over endoluminal strut surface in the straight vessel. From stage I to stage II, WSS increased by 100% and 142% over the inflow and outflow surfaces, respectively, and decreased by 27% over the endoluminal strut surface. In a curved vessel, WSS change became more evident in the inner curvature with an increase of 63% over the inflow and 66% over the outflow strut surfaces. Similar analysis at the proximal and distal edges demonstrated a large increase of 486% at the lateral outflow surface of the proximal scaffold edge. 

Conclusions: The implementation of CFD simulations over virtually deployed bioresorbable scaffolds demonstrates the transient nature of device/flow interactions as the bioresorption process progresses over time. Such hemodynamic device modeling is expected to guide future bioresorbable scaffold design.


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Copyright (c) 2017 Bill D Gogas, Boyi Yang, Tiziano Passerini, Alessandro Veneziani, Marina Piccinelli, Gaetano Esposito, Emad Rasoul-Arzrumly, Mosaab Awad, Girum Mekonnen, Olivia Y Hung, Beth Holloway, Michael McDaniel, Don Giddens, Spencer B King III, Habib Samady

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