Reprogramming for cardiac regeneration

Authors

  • Christophe Michel Raynaud Qatar Cardiovascular Research Center, Qatar Foundation-Education City, Doha, Qatar
  • Faizzan Syed Ahmad 1. Qatar Cardiovascular Research Center, Qatar Foundation-Education City, Doha, Qatar 2. Department of Pharmacology, University of Oxford, Oxford, UK
  • Mona Allouba Aswan Heart Center, Magdi Yacoub Foundation, Aswan, Egypt
  • Haissam Abou-Saleh Qatar Cardiovascular Research Center, Qatar Foundation-Education City, Doha, Qatar
  • Kathy O Lui Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, USA
  • Magdi Yacoub 1. Qatar Cardiovascular Research Center, Qatar Foundation-Education City, Doha, Qatar 3. Aswan Heart Center, Magdi Yacoub Foundation, Aswan, Egypt 5. Imperial College, London, UK

Abstract

Treatment of cardiovascular diseases remains challenging considering the limited regeneration capacity of the heart muscle. Developments of reprogramming strategies to create in vitroand in vivocardiomyocytes have been the focus point of a considerable amount of research in the past decades. The choice of cells to employ, the state-of-the-art methods for different reprogramming strategies, and their promises and future challenges before clinical entry, are all discussed here.

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Published

2017-06-30

Issue

Vol. 2014 No. 3 (2014)

Section

Review articles

License

This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.