Early onset Anthracycline-induced cardiotoxicity in a 58 year-old woman with breast cancer
DOI:
https://doi.org/10.21542/gcsp.2026.s2.125Abstract
The development of left ventricle (LV) dysfunction (CTRCD) which is reported by several chemotherapeutic agents (eg. anthracyclines) is associated with poor prognosis and contributes to long-term cardiovascular morbidity and mortality. Among measures of myocardial function, echocardiography-measured peak systolic global longitudinal strain (GLS) is the most extensively studied marker and provides an easy, inexpensive, and quantitative assessment of global long-axis systolic function.
A 58 year-old woman with breast cancer on anthracycline without any cardiac symptoms was referred to our cardio-oncology clinic due to a decline in LV GLS from -21 (before anthracycline initiation) to -16 (after 3 months of recieving anthracycline) and thus the guideline directed medical treatment was initiated. Patient demonstrated LV GLS improvement 6 months later and LV GLS recovered to -20.
The recognition of CTRCD is important since early detection and treatment with heart failure treatment provide a good function recovery and long-term prognosis.
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Copyright (c) 2026 Azin Alizadeasl, Raheleh Sajadi Nia
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