The RIME trial: Are we closer to the answer of when to repair ischemic mitral regurgitation?


  • Ahmed Afifi Aswan Heart Centre, Aswan
  • Ahmed ElGuindy Aswan Heart Centre, Aswan


[first paragraph of article]

The development of mitral valve regurgitation as a result of left ventricular remodelling following myocardial infarction carries adverse implications on survival and quality of life (QOL). There is uncertainty whether mitral valve repair at the time of surgical revascularization improves survival and quality of life and enhances left ventricular reverse remodelling in patients with moderate ischemic mitral regurgitation (IMR). The Randomized Ischemic Mitral Evaluation (RIME) trial investigators tried to address this issue by studying whether repairing moderate IMR at the time of surgical revascularization can lead to more favourable outcomes compared with surgical revascularization only. Results of this multicentre, randomized, controlled trial were recently published in Circulation.






Lessons from the trials