Microvascular dysfunction in septic and dengue shock: Pathophysiology and implications for clinical management

Authors

  • Angela McBride 1. Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam 2. Brighton and Sussex Medical School, United Kingdom
  • Ho Q Chanh Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam
  • John F Fraser Critical Care Research Group, Brisbane, Australia & University of Queensland, Brisbane, Australia
  • Sophie Yacoub Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam & Centre for Tropical Medicine and Global Health, University of Oxford, United Kingdom
  • Nchafatso G Obonyo Critical Care Research Group, Brisbane, Australia & EMRI-Wellcome Trust Research Programme, Kilifi, Kenya & Initiative to Develop African Research Leaders, Kilifi, Kenya

DOI:

https://doi.org/10.21542/gcsp.2020.29

Abstract

[No abstract, showing first paragraph of article]

The microcirculation is the terminal vascular network of the systemic circulation, whose primary function is to distribute oxygen to, and remove metabolic by-products from living cells. In health, tissue perfusion is regulated by control of microvascular tone and endothelial permeability. In states of shock, however, there is a mismatch between demand for, and delivery or utilisation of oxygen in the tissues.

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Published

2020-12-06

Issue

Vol. 2020 No. 2 (2020)

Section

Research articles

License

This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.